Endocrine Abstracts

Introduction: The polycystic ovary syndrome (PCOS) is the most common endocrine disorder of women. Its clinical manifestations are characterized by infertility, hirsutism and obesity. We report two cases of PCOS but with different signs revelations.

Observation 1: 23 year old patient presenting with metabolic syndrome, with dysmenorrhea, after investigation, diagnosis of type two diabetes with PCOS.

Observation 2: Patient aged 35 years old who consults for infertility that lasts for 5 years with obesity and hirsutism, diagnosis PCOS was diagnosed according to different criteria clinico’ radiologiques.

Results: For both our patients the care first focus was weight control, changes in eating habits, promote physical activity. Introduction of an oral antidiabetic (metformin) for both our patients and correction of cardiovascular risk factors.

Discussion: Most published studies confirm that metformin improves insulin sensitivity and reduces hyperinsulinemia in PCOS in a similar manner to what is known for patients with type 2 diabetes. In addition, the reduction of the insulin is associated to hormonal changes: increase of SHBG, decrease in circulating levels of LH and hyperandrogenism, often with improvement of ovulation.

Conclusion: The polycystic ovary syndrome is a common condition affecting nearly 12% of women of childbearing age. It is characterized by an increase in plasma testosterone and LH, and insulin resistance, mainly in anovulation, diet and lifestyle rules and metformin, can give satisfactory results.