Endocrine Abstracts

Aim: FGF-21, is a member of the FGF family that is involved in biological processes such as embryonic development, cellular growth, morphogenesis, tissue repair, tumor growth and invasion, with mitogenic and cellular vital activity activity in the cytogenetic localization of 19q13.33. Breast cancer is the fatal disease most commonly seen in women and increasing in frequency and the relationship between hormones secreted from adipose tissue and some cancers has been shown in re...

Using pharmacological chaperones is one of the most common area to rescue trapped proteins from Endoplasmic reticulum (ER) or Golgi apparatus as therapeutic targets in research of some endocrine disorders. Diabetes insipidus is one of these disorders and AVPR2 is seen mostly mutated in hereditary type of the disorder. As proteins go through a journey from ribosome till the place where they function at, AVPR2 also tracks the same way as a G-protein coupled receptor. A mutation ...

Nefrojenic Diabetes insipidus is one of the typical conformational disorders result from protein misfolding and degredation or aggregation due to the mutations in AVPR2. The patients of nephrogenic Diabetes insipidus have difficulty in concentrate of urine and because of this, they have polyuria, hypoosmolar urine and hypernatremia in variable levels. To make them relieved, many treatment strategies have been studying and using dDAVP nasally is one of these strategies. Another...

Introduction: Autoimmune polyendocrine syndromes (APS) are rare endocrinopathies characterized by the coexistence of at least two glandular autoimmune diseases. APS comprise a wide spectrum of autoimmune disorders and are divided into a very rare juvenile (APS type 1) and a more common adult type with (APS 2) or without adrenal failure (APS 3). We present a patient with polyglanduler syndrome type 3a.Case report: A 39-years-old female patient was present...

Ingestion of excessive amounts of liquorice may cause significant electrolyte imbalances due to a mimicking of mineralocorticoid excess. A 70-year-old female attended hospital with palpitations and was found to have hypokalaemia. She was documented to have multiple supraventricular ectopic beats coinciding with her feeling of palpitations, This was precipitated by toxic consumption of liquorice, more than 2 kg in 72 h, to celebrate her 70th birthday. All abnormaliti...

Introduction: The polycystic ovary syndrome (PCOS) is the most common endocrine disorder of women. Its clinical manifestations are characterized by infertility, hirsutism and obesity. We report two cases of PCOS but with different signs revelations.Observation 1: 23 year old patient presenting with metabolic syndrome, with dysmenorrhea, after investigation, diagnosis of type two diabetes with PCOS.Observation 2: Patient aged 35 yea...

Introduction: Diabetes is a risk factor for pancreatic cancer and recent studies confirm this relationship. We report the case of a patient in whom an inaugural diabetes mellitus revealed a malignant vaterian ampuloma.Observation: A 56-year-old woman with a family history of type 2 diabetes consults for suspicion of type 2 diabetes, polydipsic syndrome, and all-day hyperglycaemia greater than 2 g/dl. During the interrogation, there is a loss of appetite,...

Background: The diabetes management clinics in primary health care centres in Oman aim to provide interdisciplinary diabetes management for their patients. The interdisciplinary management is proved in the literature to have successful outcomes and help the patients to reach their glycemic control fast and safe. Therefore the diabetes management in Oman follows national guidelines, which are based on IDF and AACE guidelines and support the interdisciplinary approach. Despite t...