ECE2018 ePoster Presentations Diabetes, Obesity and Metabolism (56 abstracts)
Impact of magnesium deficiency on chronic complications of type 2 diabetes
Marwa Chiboub 1 , Faten Hadjkacem 1 , Dorra Ghorbel 1 , Rim Marrekchi 2 , Mohamed Mallek 2 , Kamel Jamoussi 2 & Mohamed Abid 1
1Endocrinology-Diabetology Department, CHU Hédi Chaker, Sfax, Tunisia; 2Biochemistry laboratory CHU Hédi Chaker, Sfax, Tunisia.
Introduction: The magnesium deficiency is frequently associated with diabetes mellitus, it is also incriminated in the occurrence of diabetic complications (micro and macrovascular). Our objective was to study the correlation between magnesium deficiency (Mg) and the presence of chronic diabetic complications.
Material and methods: Prospective study that concerned type 2 diabetics (T2D). Our patients were subdivided into 2 groups G1 and G2: G1 including 17 patients with Mg deficiency, G2 including 13 patients with normal Mg status.
Results: G1 and G2 patients had a mean age of 60.4±7.5 years and 53.1±11.6 years, respectively. The sex ratio (H/F) was 0.54 in G1 and 1.6 in G2. G1 patients had a more unbalanced T2D than G2 patients. Diabetic retinopathy, diabetic nephropathy and autonomic neuropathy were observed in 37, 30 and 10% of cases, respectively. These complications were more common in G1 subjects, but without a statistically significant difference between the two groups. The prevalence of microalbuminuria was higher in G2 patients compared to G1 (15.3% vs. 6%). Lower extremity arterial disease was found only in G1 with a frequency of 6%. Coronary and cerebrovascular disease were noted more frequently in G1.
Conclusion: Several mechanisms could explain the role of Mg deficiency in the development of chronic complications of T2DM including the increase in oxidative stress resulting from Mg depletion.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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