Endocrine Abstracts

Introduction: Vitamin D deficiency is a health problem related to cardiovascular diseases, autoimmune diseases and cancers. Several studies have shown a significant prevalence of vitamin D deficiency in T1D with positive impact of supplementation on glycemic control. The objective of our work is to evaluate vitamin D status in our T1D patients

Patients and methods: Our study has included 35 patients followed for T1D, vitamin D status was ordered in all patients.

Results: The mean age of patients was 22.5 years, the sex ratio was 1.35 with female predominance. The average duration of diabetes progression was 8.8 years with extremes ranging from 0 to 26 years. The average insulin requirement was 0.85 IU/ kg/day. HbA1C was performed in 54% of our patients and showed poor glycemic control in 88% of cases. Vitamin D levels were within the normal range in 10%, insufficient in 15% and deficient in 75%.

Discussion: Vitamin D deficiency is widely prevalent in T1D, it’s able to induce pancreatic islets inflammation inducing an alteration of insulin secretion as well as insulin sensitivity and associated with poor glycemic control. Moreover, it appears that vitamin D has an effect on carbohydrate homeostasis, directly on cell B, and indirectly by regulating calcium levels since insulin secretion is calcium-dependent