ECE2018 ePoster Presentations Calcium and Bone (6 abstracts)
Bone mineral density and polymorphisms of the estrogen receptor gene,vitamin D receptor gene and collagen typei alpha 1 gene
Sonsoles Botella Martinez 1 , Patricia Restituto 2 , Monreal Ignacio 2 , Amparo Calleja 2 , Nerea Varo 2 & Macarena Rodriguez 2
1Complejo Hospitalario De Navarra, Pamplona, Spain; 2Clinica Universidad De Navarra, Pamplona, Spain.
Objectives: The aim of this study was to analyze the prevalence of some polymorphisms of the CTR-AluI, VDR-FokI, Col1A1y ER-α genes, (involved in bone metabolism), in our population. And evaluate the association of these polymorphisms with bone mineral density and fracture.
Design, Patients, and Setting: We performed an observational prospective study in pre- and postmenopausal ambulatory women (n=72 and n=152, respectively).
Intervention: Blood samples were collected at baseline to the measurement of polymorphisms. Women filled out a questionnaire and underwent bone mineral density measurement using dual-energy x-ray absorptiometry at the time of enrollment. We evaluate the incidence of fragility fracture after 1 year of follow-up
Results: The prevalence of the polymorphisms in our population was: Gen COL1A1SP1:59% SS, 20% Ss, 21% ss; Gen CTRALUI: 5% AA, 41% Aa, 54% aa; Gen ESR1PPVUII: 36%PP, 35% Pp, 29% pp; Gen ESR1XXBAI: 10%XX, 48% Xx, 42% xx; Gen VDRBBSMI: 11% BB 44% Bb, 45% bb; Gen VDRFFOKI: 40%FF, 45% Ff, 15% ff. No polymorphisms were associated with low bone mineral density (P>0.05). Only an association was found in the postmenopausal group between the polymorphism of the PolESRXX gene and the presence of osteoporotic fracture after menopause (P=0.02).
Conclusions: The osteoporosis is a complex and multifactorial disease. Our data don’t find any significant association between polymorphisms and bone mineral density. The prevalence of genotyped polymorphisms in our study is consistent with others described in the European population (except for the polymorphism of the COL1A1gene)
Volume 56
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Endocrine Abstracts
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