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Endocrine Abstracts (2018) 56 EP18 | DOI: 10.1530/endoabs.56.EP18

ECE2018 ePoster Presentations Adrenal and Neuroendocrine Tumours (28 abstracts)

Independent ACTH Cushing’s syndrome due to unilateral adrenocortical hyperplasia: two cases report

Yousra Aouinati 1, , Siham El Aziz 1, , Amal Mjaber 1, & Asmaa Chadli 1,


1Ibn Rochd University Hospital, Endocrinology Department, Casablanca, Morocco; 2Hassan II University of Neuroscience Laboratory and Mental Health, Casablanca, Morocco.


Introduction: Cushing’s syndrome adrenal’s origin coul’d be an adenoma, an unilateral carcinoma and rarely a micronodular or macronodular hyperplasia. We report the cases of two patients followed for macronodular adrenal hyperplasia hospitalized in the Ibn Rochd University Hospital, endocrinology department in Casablanca.

Case 1: A 60-year-old patient with independent ACTH Cushing Syndrome with clinical and biological signs of hypercorticism with collapsed ACTH and unilateral adrenal mass at CT. Treatment consisted of an adrenalectomy with a good evolution. The anatomopathological examination objectified a macro-nodular adrenal hyperplasia.

Case 2: A 48-year-old female presented an independent ACTH Cushing Syndrome, discovered with clinical and biological signs, with normal ACTH, and a right adrenal nodule on CT. Patient underwent right-sided adrenalectomy with good progression. Histopathological examination showed macro-nodular adrenal hyperplasia.

Discussion and conclusion: Unilateral adrenal hyperplasia is a rare etiology of ACTH-independent Cushing’s syndrome, often taken for adrenal adenoma on CT. This hence the value of histopathological examination for diagnosis confirmation.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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