Endocrine Abstracts

Contents

• Nuclear Receptors: New Roles for Nuclear Receptors in Development, Health and Disease Conference 2018
• • Plenary Lectures
  • • Exploiting multiple nuclear receptors in breast cancer

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    • Nuclear receptors and their coactivators: An entre to understanding human diseases

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    • Targeting DNA repair-AR crosstalk dysfunction in advanced prostate cancer

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• Invited Speaker
• • (1)
  • • MicroRNA regulation of androgen signalling

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    • Androgen and estrogen receptors in breast tissues: opponents or teammates?

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    • Nuclear receptors, transcriptional enhancers, and gene regulation

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    • Estrogen receptor cistromics in breast tumors: from biomarkers to novel drug targets

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    • Rapid, cytoplasmic actions of the glucocorticoid receptor impact on cell movement

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    • Androgens and endometrial function: replication, repair and regeneration

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    • Clinically-relevant contexts for AR variants in prostate cancer

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    • Direct and indirect effects of androgens on the musculoskeletal system

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    • Progesterone receptor regulation of breast cancer cell translation

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    • Modulating glucocorticoid receptor function in breast and prostate cancer

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    • Protein factors involved in 3D genome organization & transcription regulation

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    • Nuclear receptor networks in male fertility

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    • Enhancers mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer

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    • The structural basis of chromatin reprogramming by steroid receptors

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• Oral Communications
• • (1)
  • • Heterodimerization of retinoid X receptor with xenobiotic nuclear receptors occurs in the cytoplasmic compartment of cell in a ligand independent manner

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    • Stage-specific and global functions of NCOR2 in prostate cancer progression

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    • Beyond ligand activation: Disrupting LXR[alpha] phosphorylation to reprogram diet induced transcriptomes and modulate progression of metabolic diseases

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    • Rationale targeting cell plasticity in treatment resistant prostate cancer

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    • The pathogenic role of estrogen receptor beta drives in endometriosis

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    • Chemical systems biology analyses reveal dissociated glucocorticoid signaling networks in skeletal muscle

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    • Checkpoint kinase 2 and androgen receptor cross-talk regulate the DDR and prostate cancer growth

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    • Structural basis of specific DNA recognition by the estrogen-related receptor ERR

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• Poster Presentations
• • (1)
  • • Single-molecule analysis of peroxisome proliferator-activated receptor [gamma]2 and [alpha] reveal subtype specific differences in chromatin binding dynamics

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    • Next generation glucocorticoid receptor modulators

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    • Interactions between AR coregulators, TRIM24 and TRIM28, in Castrate Resistant Prostate Cancer (CRPC)

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    • Selective disruption of ER[alpha] expression in dendritic cells of lupus prone mice results in female-specific reduced survival

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    • Glucocorticoid receptor inhibits ER-mediated pro-proliferative gene expression

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    • The impact of 27-hydroxycholesterol on endometrial cancer proliferation

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    • MIR-96 regulates retinoic acid receptor gamma cross-talk with the androgen receptor to drive aggressive prostate cancer

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