UKINETS2017 Poster Presentations (1) (40 abstracts)
Grading systems in gastroenteropancreatic neuroendocrine tumours
Charlotte Hobby 1 , Meleri Morgan 2 , Aled Rees 2 , Mohid Khan 2 & Adam Christian 2
1Cardiff University, Cardiff, UK; 2University Hospital of Wales, Cardiff, UK.
Objective: To compare 3 methods of generating Ki-67% in gastroenteropancreatic neuroendocrine tumours (GEP-NETs).
Methods: Twenty-four slides were used to generate 49 images for analysis. Each image was analysed and 3 different methods were used to calculate Ki-67%.
Results: The comparison of Ki-67% from counting and estimating using the diameter (shortcut method) was strongly positively correlated, whereas the Ki-67% from counting and using ‘immunoratio’ were only weakly positively correlated.
Conclusion: Guidance from The Royal College of Pathologists 2017 states that clinicians must now count 2000 cells from hotspots within the tissue sample to calculate a Ki-67%. The shortcut method gives reasonably accurate results, the online ‘immunoratio’ is less reliable.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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