Endocrine Abstracts

Severe insulin resistance (SIR) is an umbrella term which encompasses a number of clinical conditions, all of them rare. This talk will use a case based approach to demonstrate a practical approach to the investigation and management of severe insulin resistance and will include severe insulin resistance secondary to insulin signalling defects and to different forms of lipodystrophy. The aim of the talk will be to provide clinicians with a useful framework to approach the clinical diagnosis and give guidance regarding appropriate investigations. Key Learning Points:

i) What is the definition of severe insulin resistance?

ii) What are the clinical features of the different forms of severe insulin resistance?

iii) What investigations should be done?

iv) What are the available treatments?