Oral Communications 2

ea0051oc2.1 | Oral Communications 2 | BSPED2017

Discordant TSH measurements in an euthyroid child due to a homozygous TSHbeta subunit gene variant with variable immunoreactivity

van Walree Eva , Hendriks A Emile J , Moran Carla , Nicholas Adeline K , Lyons Greta , McGowan Anne , Halsall David , Oddy Sue , Chatterjee V Krishna , Schoenmakers Nadia

Introduction: Thyroid function tests are frequently undertaken in children with non-specific symptoms suggestive of thyroid dysfunction. Infrequently, susceptibility of automated thyroid hormone assays to interference may generate misleading results, with the potential for inappropriate diagnosis and management. We report an unusual case with apparent subclinical hyperthyroidism, due to negative interference in particular TSH assay platforms, with an underlying genetic basis.<...

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ea0051oc2.2 | Oral Communications 2 | BSPED2017

Evolving primary adrenal insufficiency masked by adrenal suppression from long-term steroid treatment

Vasista Pooja , Shenoy Savitha

Introduction: Adrenal suppression secondary to long-term steroid therapy is a known risk and this can mask the evolution of primary adrenal insufficiency.Case report: A 6 years old girl with background of recurrent oral ulcers (probable mucocutaneous Behcets), Alpha-1-Antitrypsin deficiency, Bronchiectasis, on long-term oral Prednisolone treatment, was noted to have hyponatraemia (Na=122 mmol/l) and hyperkalaemia (K=6.6 mmol/l) during an inter-curr...

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Endocrine Abstracts

45th Meeting of the British Society for Paediatric Endocrinology and Diabetes

Oral Communications

Discordant TSH measurements in an euthyroid child due to a homozygous TSHbeta subunit gene variant with variable immunoreactivity

Evolving primary adrenal insufficiency masked by adrenal suppression from long-term steroid treatment

BiosciAbstracts