SFEBES2017 Poster Presentations Obesity and Metabolism (31 abstracts)
1Department of Endocrinology, Salford Royal NHS Foundation Trust, Salford, UK; 2Manchester Medical School, The University of Manchester, Manchester, UK.
Background: Bariatric surgery for severe obesity can lead to micronutrient/vitamin deficiencies.
Aim: To study baseline and post-surgical prevalence of vitamin D deficiency in patients undergoing bariatric surgery.
Setting: University teaching hospital in North-West England.
Methods: We performed an observational cohort analysis of longitudinal data on vitamin D and related parameters in patients who underwent bariatric surgery. Patients were routinely recommended daily combined calcium and vitamin D supplementation post-surgery.
Results: We studied 480 patients with a median age of 48.8 years, weight 139.3 kg and body mass index 49.3 kg/m2 who underwent gastric bypass (277; 58.9%), sleeve gastrectomy (168; 35.7%) or other primary bariatric surgery (25 patients; 5.3%). Median vitamin D level was significantly lower at baseline and improved with supplementation post-surgery (Table 1). Whereas 52.8% had vitamin D deficiency (<30.0 nmol/l) and 25.1% insufficiency (≥30.0 <50.0 nmol/l) preoperatively, 13.3 and 23.0% had deficiency and insufficiency, respectively, at 12 months with similar trends up to 4 years of follow-up.
Conclusion: Vitamin D deficiency and insufficiency were commonly prevalent pre-surgery, which reduced significantly with routine supplementation post-surgery.
Outcome measures† | 0 months | 12 months | 24 months | 36 months | 48 months |
Body mass index (kg/m2) | 49 | 34**** | 34**** | 36**** | 37**** |
Vitamin D (nmol/l) | 30 | 57**** | 56**** | 50**** | 53**** |
Parathyroid hormone (pmol/l) | 5.0 | 5.4 | 5.3 | 5.5 | 5.6 |
Corrected calcium (mmol/l) | 2.33 | 2.29 | 2.28**** | 2.24**** | 2.28**** |
Phosphate (mmol/l) | 1.05 | 1.14**** | 1.09 | 1.07 | 1.10 |
Alkaline phosphatase (U/l) | 81 | 82 | 77 | 83 | 78 |
†Median | ****P<0.0001 (compared to baseline) |