SFEBES2017 Poster Presentations Obesity and Metabolism (31 abstracts)
Genes involved in zinc homeostasis are associated with metabolic syndrome and insulin resistance in Romanian and French populations
Mirela Diana Ilie 1, , Sara Haydar 2 , Madalina Vintila 1 , Corinne Lautier 2 , Christophe Normand 2 , Monica Gheorghiu 1 , Catalina Poiana 1 , Corin Badiu 1 & Florin Grigorescu 2
1“C.I.Parhon” National Institute of Endocrinology, Bucharest, Romania; 2Montpellier University, Iurc, Nutripass – UMR204, Montpellier, France.
Introduction: Zinc homeostasis is involved in numerous physiological and pathological conditions, ranging from type 1 and type 2 diabetes to memory impairment and cancer, and is determined by at least 28 genes, including 24 SLC (Solute Carrier) family members and 4 MTs (Metallothioneins). To explore the potential role of zinc homeostasis in MetS (metabolic syndrome) and IR (insulin resistance), we investigated 28 candidate genes by gene-SNPing.
Methods: A number of 1304 SNPs (single nucleotide polymorphism) were genotyped with the Affymetrix MEDISCOPE GeneChip in 483 subjects (123 cases of MetS and 360 controls) from two ethnic European populations – Romanian and French (MEDIGENE collection). Genetic association was tested by logistic regression, whereas quantitative variables were tested by correlation trend test. Bonferroni correction and false discovery rate were applied.
Results: The most significant association was found with MetS and concerned 3 SNPs located on Chr10 between SLC39A12 and CACNB2 genes: rs7083207, rs17602947 and rs7903081 (Bonferroni P<0.03) with OR 2.15, 95% CI [1.5-3.0], OR 2.07, 95% CI [1.46-2.95] and OR 1.99, 95% CI [1.43-2.78], respectively. These 3 SNPs were also associated and/or correlated with the different components of MetS, notably with hypertriglyceridemia (OR 2.09, 95% CI [1.42-3.07], P<7.8×10-5), but not associated with IR, nor correlated with HOMA-IR index of IR. The most significant association with IR was found for SLC39A11 gene located on Chr17 (OR 2.95, 95% CI [1.68-5.18], Bonferroni P<0.05), which was also concordantly correlated with low HDL cholesterol and HOMA-IR.
Conclusions: Genes involved in zinc homeostasis are good determinants of MetS and IR, although different genes are implicated. SLC39A12/CACNB2 on Chr10 and SLC39A11 on Chr17 were the most concordantly associated and correlated with MetS and IR, respectively.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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