Endocrine Abstracts

Short sleep duration and insomnia have been linked to higher risk of cardiovascular disease and CVD related mortality. Likewise, obstructive sleep apnea has been shown to confer a higher cardiovascular risk and is reported to be associated with 52-70% of acute myocardial infarctions and strokes. Hypertension (HTN), diabetes (DM), weight gain, sleepiness, fatigue and depression have all been correlated with obstructive sleep apnea (OSA). Patients with pituitary adenomas (PA), particularly those with Cushing’s disease and acromegaly, often present with reported sleep dysfunction, fatigue and metabolic risk factors, diabetes, hypertension and cardiovascular disease and depression. The prevalence of sleep apnea in patients with pituitary hypersecretion at diagnosis has not been clearly quantified in patients as it may not be recognized and may go undiagnosed at the time of presentation. Additionally, the correlation with diabetes and other cardiovascular risk factors is not clear in these disorders. There is little data regarding the impact of treatment and disease remission on both OSA and persistent risk factors. The aim of this presentation is to explore the prevalence and correlation between sleep disturbance (SD), depression, BMI, HTN, diabetes Mellitus (DM), pituitary deficiencies (PD), tumor size, diagnosis and risk of OSA for patients with PA pre and post treatment remission. Data from one institution will be presented.