ECE2017 Symposia Guided session 1 (6 abstracts)
Denmark.
Turner syndrome (TS) affects 2550 per 100 000 females and can involve multiple organs through all stages of life, necessitating a multidisciplinary approach to care. Previous guidelines have highlighted this, but numerous important advances have been noted since their publication. These advances cover all specialty fields involved in the care of girls and women with TS. This new international guideline is based on an international effort that started with exploratory meetings in 2014 in both Europe and the USA, and culminated with a Consensus Meeting held in Cincinnati, Ohio, USA in July 2016. Prior to this meeting, five groups each addressed important areas in TS care: i) diagnostic and genetic issues, ii) growth and development during childhood and adolescence, iii) congenital and acquired cardiovascular disease, iv) transition and adult care, and 5) other comorbidities and neurocognitive issues. These groups produced proposals for the new guidelines. Additionally, four pertinent questions were submitted for formal GRADE (Grading of Recommendations, Assessment, Development and Evaluation) evaluation with a separate systematic review of the literature. These four questions related to the efficacy and most optimal treatment of short stature, infertility, hypertension, and hormonal replacement therapy. These guidelines were initiated and developed by the European Society of Endocrinology (ESE) in Europe, and by the Pediatric Endocrine Society (PES) in USA, with important contributions from the European Society of Human Reproduction and Embryology (ESHRE), the Endocrine Society (ES), the European Society for Cardiology (ESC), the American Heart Association (AHA), and the European Society for Pediatric Endocrinology (ESPE). Several delegates from other societies also participated. Advocacy groups appointed representatives who participated in pre-meeting discussions and in the consensus meeting. Here, we will present the most important new advances in the care of Turner syndrome.