ECE2017 Eposter Presentations: Pituitary and Neuroendocrinology Pituitary - Clinical (145 abstracts)
Four decades without diagnosis: Sheehan‘s syndrome, a retrospective analysis
Deniz Gokalp 1 , Gulistan Alpagat 2 , Alpaslan Kemal Tuzcu 1 , Mithat Bahçeci 3 , Sadiye Tuzcu 4 , Fatime Yakut 5 & Azat Yildirim 6
1Department of Endocrinology, Acibadem Medical University, Istanbul, Turkey; 2Department of Endocrinology, Dicle University School of Medicine, Diyarbakir, Turkey; 3Izmir Ataturk Education and Research Hospital, Izmir, Turkey; 4Department of Nuclear Medicine, Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey; 5Department of Radiology, Diyarbakir Memorial Hospital, Diyarbakir, Turkey; 6Azad Yildirim Department of Orthopedics, Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
Aim: Sheehan‘s syndrome (SS) remains a frequent cause of hypopituitarism in undeveloped and developing countries, but due to improvements in obstetric care, it is rare in developed countries. We aimed to share the results of a retrospective study analyzing the demographic, clinical, imaging, and hormonal characteristics of a large group of patients with SS, and also increase awareness of this syndrome especially in developed countries.
Methods: The medical records of 124 patients with SS patients who were followed up in the Endocrinology Department of Dicle University between 1995 and 2015 were assessed retrospectively.
Results: The mean period of diagnostic delay was 20.37±8.34 years on average. 5.7% of patients with SS were literate; 62% of patients delivered at home. Anemia was identified in 64.5% of SS patients. Mean blood sodium levels were 129.8±11.3 mEq/L. The mean urine densities were 1013±6.5. Osteoporosis and osteopenia were found in 44 (35.4%) and 71 (57.2%) patients, respectively, According to pituitary magnetic resonance imaging (MRI) analyses, 92 (74.2%) patients with SS had completely empty sella, 29 (23.3%) had partially empty sella, and 1 patient had microadenoma, and 2 had normal pituitary MRI results.
Conclusions: Improved obstetric care and effective interventions for postpartum hemorrhage have limited the prevalence of SS in developed countries. However, in developing countries like Turkey, SS due to postpartum bleeding remains common. Thus, physician’s awareness of the symptoms of SS is urgently required to avoid the associated morbidity and mortality.
Keywords: Hypothalamic amenorrhea, osteoporosis, pituitary gland
Volume 49
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more