ECE2017 Eposter Presentations: Pituitary and Neuroendocrinology Neuroendocrinology (33 abstracts)
Predictors of remission after transsphenoidal adenomectomy in patients with Cushing’s disease
Eugenia Marova , Galina Kolesnicova , Svetlana Arapova , Andrey Grigoriev & Anasteysa Lapshina
Endogrinology Research Centre, Moscow, Russia.
Abstract: Cushing’s disease (CD) is the heavy disease of the hypothalamic–pituitary–adrenal axis. The cause of the disease is pituitary adenoma (corticotropinoma). Hypersecretion of ACTH by a pituitary adenoma leads to increased secretion of cortisol by the adrenal cortex and the development of total endogenous hypercortisolism. The gold standard treatment for this disease is surgical removal of corticotropinoma. However, adenomectomy is not effective in all cases and approximately 20% of cases after the radical treatment fails to achieve remission of the disease and then comes the relapse. The aim of our work was to evaluate the factors influencing the result of adenomectomy in patients with the Cushing’s disease and identification of recurrence predictors. Materials and methods: retrospective assessment of clinical and hormonal factors in 84 patients with CD, influencing early and long-term results of adenomectomy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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