ECE2017 Eposter Presentations: Pituitary and Neuroendocrinology Neuroendocrinology (33 abstracts)
The prevalence of colorectal cancer and colon polyps in acromegaly: thirty years’ experience of a tertiary referral center
Vânia Gomes , Luís Barreiros , Eduardo Barreiros , Florbela Ferreira , Ana Gomes , Ana Filipa Martins , Ana Sofia Osório , Ana Wessling , Catarina Silvestre , Dinis Reis , Ema Nobre , Maria Raquel Carvalho , Mário Mascarenhas , Sónia do Vale , José Miguéns & Maria João Bugalho
Santa Maria Hospital, Lisbon, Portugal.
Introduction: Several studies suggest a higher risk of colorectal cancer (CRC) and colon polyps (CP) in acromegaly, however there is still controversy regarding associated factors (AF) able to contribute for its development. Data on the prevalence of CRC and CP in Portuguese patients with acromegaly are limited.
Objectives: To assess the prevalence of CRC and CP in acromegalic patients and compare to the normal Portuguese population. To determine the relevance of a number of AF (growth hormone, insulin-like growth factor-1, body mass index and age at diagnosis, gender, diagnostic delay and disease duration) for its development.
Methods: Retrospective study of 101 acromegalic patients assisted in a tertiary center from 1985 to 2016, who underwent at least one colonoscopy. Comparative analysis with data from screening studies conducted in the normal Portuguese population. Statistical analysis was performed with SPSS software, version 20. Statistical significance: P< 0.05.
Results: Of the 101 patients (female: 62.4%; mean age at diagnosis: 49.5±12.8 years), 47.5% presented abnormal colonoscopy with CP, which were more frequent in the left colon. Histological analysis identified hyperplastic polyps (HP) in 29.7% of the patients, adenomas in 16.8% and CRC in 5%. In total, 27 adenomas and 69 HP were detected. The prevalence of CRC, CP and adenoma found in this study compared to normal population was: 5 vs 1% (P=0.001); 47.5 vs 32.6% (P=0.003) and 16.8 vs 38% (P=0.001), respectively. Concerning AF, there was no differences between patients with abnormal and normal colonoscopy.
Conclusions: The prevalence of CRC and CP was significantly higher in patients with acromegaly. On the contrary, adenoma was significantly less prevalent. No association between any of the factors studied and the phenotype CRC/CP was observed. To our knowledge, this is one of the largest Portuguese series, nevertheless results have yet to be validated.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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