Endocrine Abstracts

Context: Many pediatric cancer survivors have endocrine conditions. After alkylating agents, steroids, methotrexate and radiation, several endocrine dysfunctions may appear. Surveillance for late effects is recommended by worldwide guidelines.

Objective: The objective of the study was to describe the endocrine outcomes of 764 patients followed during a 20 years period in our out-patient clinic.

Design: The design was a retrospective medical records review.

Patients: The study included 764 patients whose oncological or hematological dangerous diseases appeared before 18 years old. Larger groups were constituted by Leukaemias, Central Nervous Tumors and Lymphomas.

Outcome measures: The frequency and types of endocrine conditions were measured.

Results: One thousand and ninety one endocrine conditions were observed in all groups. The most common types of endocrine conditions were problems with growth and thyroid. We found puberty abnormalities and bone problems in third and fourth places of frequency. ACTH insufficiency was found in seventh place.

Conclusion: Endocrine dysfunctions are very common in survivor’s population. Endocrinologists should be aware of international guidelines and to make an effort to optimize screening and treatment of endocrine effects of cancer therapy. The crucial period is the pubertal with growth spurt failure and acceleration puberty maturity wisch of them can bring future social and professional difficulties.