Endocrine Abstracts

The term polyglandular autoimmune syndrome (PAS) is used when there is a dysfunction of two or more endocrine glands associated with circulating antibodies directed at organspecific included glands. Neufeld and Blizzard classified PAS into two categories: type I and type II with the newly added category, type III, which does not include the adrenal cortex. PAS III includes several autoimmune diseases (autoimmune thyroiditis, immune-mediated diabetes mellitus, pernicious anemia, vitiligo, alopecia areata, and many others) and is divided into four sub-categories. We report a 44-year-old patient who was hospitalized in August 2016 at our department with suspected polyglandular autoimmune syndrome. In 2013 he was repeatedly evaluated at gastroenterology department where were established the diagnoses of primary hemochromatosis (homozygous mutation in the gene p C282Y HFE), Crohn’s disease and celiac disease, as well as candidiasis in May 2016. In our department, the endocrinological testing establish the existence of autoimmune thyroiditis (anti -TG 207.1 IU/ml; antiTPO 141.0 IU/ml) without disorders of thyroid function and the presence of insulin resistance.