ECE2017 Eposter Presentations: Interdisciplinary Endocrinology Cardiovascular Endocrinology and Lipid Metabolism (9 abstracts)
An investigation into role of circulating concentrations of vitamin D and calcium in the development of hypertension and related cardiovascular diseases
Saba Nazir 1 , Nadia Afzal 1 , Maleeha Akram 1 , Zubaria Iqbal 1 , Abida Raza 2 , Mazhar Qayyum 1 , Afzaal Ahmed Naseem 1 , Syed Ali Raza Kazmi 3 , Faheem Tahir 4 , Kiran Afshan 5 , Sarwat Jahan 5 & Syed Shakeel Raza Rizvi 1
1Department of Zoology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi/Punjab, Pakistan; 2Department of Biophotonics, National Institute of Laser and Optrionics (NILOP), Nilore/Islamabad, Pakistan; 3Aga Khan Health Centre, Rawalpindi/Punjab, Pakistan; 4Reproductive Physiology, Public Health Laboratories Division, National Institute of Health (NIH), Islamabad, Pakistan; 5Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Vitamin D plays a key role in the control of cardiovascular diseases (CVDs), acting as negative regulator of renin-angiotensin-aldosterone-system (RAAS), whereas calcium directly affects central blood pressure (BP) control center, nucleus tractus solitarus. We investigated associations between plasma concentrations of vitamin D and calcium and BP in 100 hypertensive CVDs patients and 100 normotensive subjects of 21–60 years. Vitamin D concentrations were measured using ECLIA system, whereas calcium concentrations were determined using spectrophotometric system. Data were analyzed using Student’s t-test, ANOVA and Pearson correlation r. Out of 10 RAAS inhibitors (RAASi) treated patients, nine were vitamin D deficient and one was vitamin D insufficient. Of 29 non-RAASi treated patients, 28 were vitamin D deficient and one was vitamin D insufficient. Among 36 patients treated with combination of RAASi and non-RAASi, 35 were vitamin D deficient and one was vitamin D insufficient. Out of 25 untreated patients, 22 were vitamin D deficient and three were vitamin D insufficient. Ninety one control subjects were vitamin D deficient, eight were vitamin D insufficient and one was vitamin D sufficient. In patients treated with RAASi, calcium concentrations were at lower limit of normal range in 7 and at upper limit in 3. In non-RAASi treated patients, calcium concentrations were at lower limit in 13 and at upper limit in 16. In both RAASi and non-RAASi treated patients, calcium concentrations were at lower limit in 27 and at upper limit in 9. In untreated patients, calcium concentrations were at lower limit in 15 and at upper limit in 10. In control subjects, calcium concentrations were at upper limit in 21, at lower limit in 77 and below lower limit in 2. There were weak correlations between vitamin D and calcium concentrations and mean BP and systolic and diastolic BP in all patients.
Volume 49
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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