ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Obesity (81 abstracts)
Prevalence of mono-ethyl-hexyl phthalate and mono-ethyl phthalate in Serbian population and their influence on leptin and thyroid function in obesity
Ivana Bajkin 1, , Natasa Milic 2, , Jovanka Novakovic-Paro 1, , Tijana Icin 1, , Jovana Prodanovic 1 , Nikola Curic 2, , Bojan Vukovic 1, & Milica Medic-Stojanoska 1,
1Clinic of Endocrinology, Diabetes And Metabolic Disorders, Clinical Center of Vojvodina, Novi Sad, Vojvodina, Serbia; 2Faculty of Medicine, University of Novi Sad, Novi Sad, Vojvodina, Serbia; 3Department of Pharmacy, University of Novi Sad, Novi Sad, Vojvodina, Serbia; 4Center for Laboratory Medicine, Clinical Center of Vojvodina, Novi Sad, Vojvodina, Serbia.
Introduction: Phthalates are ubiquitous endocrine disruptors (EDs). EDs induce obesity. MEP and MEHP affect thyroid function.
Aim: Estimation of burden of MEP and MEHP in our population, evaluation of leptin in obese MEP and MEHP positive and negative subjects and evaluation of connection between leptin, MEP, MEHP and thyroid indicators in that subgroup. Materials and methods: a cross-sectional study, with 201 subjects divided into MEP/MEHP positive and negative, subdivided in obese and lean. Anthropometric parameters done: body height, weight, waist and body mass index. Laboratory tests: morning urine sample for MEP/MEHP and venous sample for free thyroxine (FT4), free tri-iodothyronine (FT3), thyroid stimulating hormone (TSH) and leptin. Statisycal analysis was done in SPSS. Results: Mean age of participants was 36.74 (±8.55) years, 86 (42.8%) males and 115 (57.2%) females. There were 64 (31.2%) MEP+, and 44 (22%) MEHP+ participants, and 5 (5.05%) positive for both. There were 93 (46.3%) participants in obese subgroup, MEHP- 64 (68%), MEHP+29 (32%; MEP− 58(62%), MEP+38%). Independent t-test and Mann Whitney U test did not show statistical significance in leptin level neither in MEP+ and MEP− (t −0.316, P<0.753; Z −0.242, P<0.809), nor in MEHP+ and MEHP− obese participants (t −1.049, P<0.297; Z −1.377, P<0.169). Pearson correlation for leptin and FT4 in obese MEP+ subgroup was statistically significant (r −0.347, P<0.041). No significant correlations were found for leptin with FT3 (r −0.123, P<0.48) and TSH (r 0.078; P<0.655). In MEHP+ obese patients we did not find any significance (FT4: r 0.189, P<0.25; FT3: r −0.023, P<0.897; TSH r 0.062, P<0.928).
Conclusion: Half of our population is exposed to MEHP and MEP. In obese subjects higher leptin correlates with lower FT4.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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