ECE2017 Eposter Presentations: Adrenal and Neuroendocrine Tumours Adrenal cortex (to include Cushing's) (86 abstracts)
Adrenocortical carcinoma in pregnancy
Goknur Yorulmaz 1 , Nur Kebapci 1 , Funda Canaz 2 , Betul Aydin Buyruk 1 , Sevil Alaguney 1 , Bartu Badak 3 & Mahmut Kebapci 4
1Division of Endocrinology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey; 2Department of Pathology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey; 3Department of General Surgery, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey; 4Department of Radiology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey.
Introduction: Adrenocortical carcinoma (ACC) is a very rare tumor. The mean age at onset is between 40 and 50 years. Patients with nonfunctioning ACC report symptoms of abdominal discomfort or back pain due to the large tumor size. Surgery for ACC should be performed by an expert surgeon.
Case: A 29-year-old patient with 25 weeks of pregnancy admitted at our clinic with right side pain. 10×11 cm solid mass on right adrenal gland was detected by ultrasonography. The lactate dehydrogenase level of the patient was 10 times higher than normal ranges. The urinary metabolits were within normal limits. Because of the increase in the size of the mass, the patient underwent operation urgently. The histopathological report indicates an adrenocortical carcinoma and tumor weighting 376 g and measuring 10×9×7 cm. The patient gave birth on the 32nd gestational week. The patient was evaluated after delivery and liver, pulmonary and brain metastases were detected. One week after delivery patient was died in intensive care unit.
Conclusion: Several clinical data shown that the secretion and or proliferation of adrenocortical tumors may have be affected by the hormonal context of pregnancy. Most of patients present with excess steroid hormone or abdominal mass effects. In our patient, a mass was detected in the ultrasonography performed with the cause of side pain. In pregnancy treatment procedure was not still standardized in ACC, but ACC was an aggressive malignant tumor, so our patient was operated urgently. Because of her pregnancy chemotheraphy was planned after birth. But one week after delivery patient was died.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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