ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Obesity (81 abstracts)
Lipid profiles and vitamin D receptor polymorphisms in overweight/obese dialysis patients
Gokhan Bagci 1 , Can Huzmeli 2 , Binnur Bagci 3 , Ferhan Candan 2 , Lale Akkaya 2 & Mansur Kayatas 2
1Cumhuriyet University, Medical Biochemistry, Sivas, Turkey; 2Cumhuriyet University, Nephrology, Sivas, Turkey; 3Cumhuriyet University, Nutrition and Dietetics, Sivas, Turkey.
Background: Vitamin D receptor (VDR) is present on adipocytes, and many studies were carried out to investigate the association between single nucleotide polymorphisms (SNPs) in VDR gene with obesity. However, little is known about the role of VDR gene polymorphism with obesity in dialysis patients. Therefore, we aimed to investigate lipid profile and VDR gene TaqI, ApaI and FokI SNPs in overweight/obese dialysis patients.
Methods: Seventy one normal weight and 68 overweight/obese patients were included in study. PCR-RFLP method was used for genotyping.
Results: For all three SNPs, no significant association was found between normal and overweight/obese patients (P>0.05). The level of LDL, total cholesterol and triglycerides was found significantly high, and HDL level was found significantly low in overweight/obese patients compared to normal weight patients (P<0.05). In overweight/obese patients, patients carrying ApaI CC genotype have higher triglyceride levels compared to AA and AC genotype (CC vs AA P=0.001; CC vs AC P<0.001) and CC =627±653; AC =193±85; AA =233±156). No significant association was found between other SNPs and lipid profiles.
Conclusions: Our results suggest that ApaI polymorphism are associated with high triglyceride levels in overweight/obese dialysis patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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