ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Obesity (81 abstracts)
The association of anthropometric measurements and PPAR-γ gene expression among healthy adult subjects
Maryam Zarkesh 1 , Emad Yuzbashian 2 , Azita Zadeh-Vakili 1 , Kimia Tabaei 3 , Afsoon Daneshafrooz 1 , Golaleh Asghari 2 , Parvin Mirmiran 2 , Mehdi Hedayati 1 & Alireza Khalaj 4
1Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3School of Advanced Sciences in Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; 4Tehran Obesity Treatment Center, Department of Surgery, Shahed University, Tehran, Iran.
Introduction: Peroxisome proliferator activated receptor-γ (PPAR-γ) is a distinguished transcription factor abundantly expressed in the adipose tissues and plays a key role in the regulation of adipocyte differentiation and development of obesity. In the current study, we aimed to investigate the association of PPAR-γ mRNA expression in omental and subcutaneous adipose tissues with anthropometric indices and blood pressure (BP) among healthy adults.
Methods: 97 subjects (41 non-obese, 18 obese, and 38 morbid obese) were eligible for the study. Omental and subcutaneous adipose tissues were obtained during open abdominal surgery. The PPAR-γ mRNA level was evaluated in omental and subcutaneous adipose tissues using Real-Time PCR assay. Height, weight, BMI, waist, hip, and neck circumferences, and BP were determined according to standard protocols.
Results: The mean of BMI was 24.8, 34.9, and 46.8 kg/m2 in morbid obese, obese and non-obese subjects, respectively. PPAR-γ gene expression was not significantly different between omental and subcutaneous adipose tissues in each group. However, PPAR-γ mRNA expression was down-regulated in omental adipose tissues of non-obese subjects compared to obese subjects and up-regulated compared to morbid obese ones (P<0.05). Among morbid obese subjects, diastolic and systolic blood pressures were positively correlated with omental PPAR-γ expression (r=0.409, P=0.020 and r=0.371, P=0.037, respectively); waist and neck circumferences were positively correlated with both adipose tissues (P<0.05). Among obese subjects, PPAR-γ expression in both tissues had significant positive correlation with waist circumference (P<0.05).
Conclusion: Our study suggested that several obesity-related indices have a positive correlation with PPAR-γ expression in omental and subcutaneous adipose tissues.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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