ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Nuclear receptors and Signal transduction (1 abstracts)
Dietary intake of linoleic, linolenic, oleic, and arachidonic acid PPAR-gamma gene expression in visceral and subcutaneous adipose tissue among healthy subjects
Emad Yuzbashian 1, , Maryam Zarkesh 3 , Golaleh Asghari 1 , Azita Zadeh-Vakili 3 , Behnaz Mahmoodi 1 , Afsoon Daneshafrooz 3 , Mehdi Hedayati 3 & Parvin Mirmiran 1
1Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Student Research Committee, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 3Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objective: To investigate whether peroxisome proliferator-activated receptor gamma (PPAR-gamma) gene expression in visceral and subcutaneous adipose tissue was related to intake of several fatty acid intakes.
Methods: For the current study 97 subjects (41 non-obese, 18 obese, and 38 morbid obese) were selected. All of the subjects were free of diabetes and cancers and without using anti-lipid medication. Visceral and subcutaneous adipose tissues were obtained during an abdominal open surgery with minimal impact on dietary intake. The PPAR-gamma gene expression was assessed by Real-Time PCR. Usual dietary intake was measured using a validated semi-quantitative food frequency questionnaire. For calculation linoleic (18:2), linolenic (18:3), oleic (18:1), and arachidonic acid (20:4) intakes, the USDA Food Composition Table was used.
Results: The PPAR-gamma expression in visceral adipose tissue among non-obese subjects was correlated with oleic acid (r=−0.417, P=0.007) and linoleic acid (r=−0.401, P=0.009). Were seen significant correlations between subcutaneous adipose tissue PPAR-gamma expression and linoleic acid (r=−0.310, P=0.049) among non-obese subjects. PPAR-gamma expression among obese subjects in visceral adipose tissue was correlated with oleic acid (r=−0.686, P=0.002) and linolenic acid (r=−0.699, P=0.031) and also in subcutaneous adipose tissue was correlated with oleic acid (r=−0.453, P=0.048). Furthermore, among morbid-obese subjects PPAR-gamma expression in visceral adipose tissue was correlated with linoleic acid (r=−0.336, P=0.039) and in subcutaneous adipose tissue was correlated with linoleic acid (r=−0.326, P=0.046) and oleic acid (r=−0.352, P=0.030). Were seen no significant association of dietary intakes of arachidonic acid with PPAR-gamma gene expression.
Conclusions: PPAR-gamma gene expression was negatively correlated with linoleic and oleic acids among non-obese and obese subjects.
Conflict of Interest: None of the authors has any personal or financial conflict of interest.
Funding: Not applicable.
Volume 49
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Endocrine Abstracts
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