ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Diabetes complications (102 abstracts)
The prevalence of chronic kidney disease and albuminuria in patients with Type 1 and Type 2 diabetes attending a single centre
MS Majeed , G Boran , LA Behan , M Sherlock & J Gibney
Departments of Endocrinology1, and Chemical Pathology 2, The Adelaide and Meath Hospital, Incorporating the National Children’s Hospital, Tallaght, Dublin 24, Dublin, Ireland.
Chronic kidney disease (CKD) is an important complication of diabetes and determinant of mortality. Albuminuria represents early diabetic nephropathy, and also indicates generalised vascular dysfunction. Understanding the epidemiology of CKD and albuminuria helps inform health planning and identify opportunities to prevent or delay progression of diabetic kidney disease. The last available serum creatinine and urine albumin/creatinine ratio (UACR) in patients with Type 1 (T1DM) or Type 2 (T2DM) diabetes recorded on the DIAMOND database were used for analysis. Patients were divided into tertiles of age. CKD was defined as eGFR<90 ml/min; microalbuminuria as UACR>2.5 mg/mmol (male), >3.5 mg/mmol (female); macroalbuminuria as UACR>20 mg/mmol. NA-normal albumin excretion; MA-microalbuminuria; A-macroalbuminuria; ND-not done CKD was common and increased with age. Microalbuminuria also increased with age and was similar in patients with and without CKD. Macroalbuminuria was uncommon. In summary, CKD is common in hospital-based diabetic patients. The low prevalence of macroalbuminuria indicates that this mostly does not reflect classical diabetic nephropathy.
| T1DM, CKD | T1DM, No CKD | T2DM, CKD | T2DM, No CKD | |
| Number/ % | Number/ % | Number/ % | Number/ % | |
| (%NA/MA/A/ND) | (% NA/MA/A/ND) | (%NA/MA/A/ND) | (%NA/MA/ND) | |
| Age 18–58 | 271/ 27% | 732/ 73% | 721/ 42% | 978/ 58% |
| (n=2702) | (60/ 13/ 6/ 21) | (51/ 10/ 1/ 38) | (56/ 14/ 4/ 26) | (60/ 13/ 6/ 21) |
| Age 58–71 | 106/ 75% | 36/ 25% | 1736/ 67% | 826/ 33% |
| (n=2704) | (56/ 19/ 5/ 20) | (45/ 23/ 6/ 26) | (50/ 17/ 5/ 28) | (50/ 17/ 5/ 28) |
| Age 71–107 | 54/ 85% | 9/ 15% | 2244/ 84% | 397/ 16% |
| (n=2704) | (20/ 31/ 6/ 43) | (44/ 22/ 11/ 23) | (40/ 28/ 6/ 26) | (47/ 20/ 5/ 28) |
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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