Endocrine Abstracts

Osteoarthritis is a great public health problem indiscriminately; ie goanrthritis, coxarthritis or dejenerative spine diseases. Osteoarthritis is focude sixth decades in elderly people, espicially in women. Many studies assingned the efficiancy of Diabetes Mellitus in the etiology of Osteoarthritis. Correlations between bone-destructive characteristics and carbohydrate metabolism errors is now quite accused in this clinical views. A comparing between Diabetes Mellitus Type 1 and 2 is aimed in this study which one cause in much more osteoarthritis. 167 (69 gonarthroisis, 57 coxarthritis and 41 dejenerative spine diseases) patients is joined to this trials for 4 years. All patients were evaluated by endocrinologists and orthopaedists. According to results; there were more counts of Type 2 patients in all groups (51 Type 2 and 18 Type 1 in gonarthrosis; 46 Type 2 and 11 Type 1 in coxarthritis, 32 Type 2 and 9 Type 1 in dejenerative spine diseases). Statistical difference is significiant (P<0.05). Many recently clincal and laboratory studies assigned a correlations between Diabetes Mellitus and all rheumatoid diseas. Carbohydrate metabolism is a headstone of all metabolic systems. All defects and errors in carbohydrate metabolism can affect other metabolic systems and bone-soft tissue systems by the metabolits, especially sorbitol. And also presdisposition of Type 2 to Metabolic Syndrome can mark pathophyisology of Osteoarthritis as difference proportions of these types.