ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Diabetes complications (102 abstracts)
The value of blood glucose levels for the parameters of nocturnal sleep for patients with type 1 diabetes
Ina Darashkevich 1 , Tatiana Mochort 2 , Lola Niconova 1 & Serhey Tishkovsky 1
1Grodno State Medical University, Grodno, Belarus; 2Belarus State Medical University, Minsk, Belarus.
Objective: To establish the differences in terms of sleep for patients with type 1 diabetes, depending on the level of blood glucose levels (BGL) during the night.
Materials and methods: The study included 43 participants with type 1 diabetes (Group A – patients with BGL during sleep from 3.9 to 7.4 mmol/l, Group B – 7.5–10.0 mmol/l. Patients had daily monitoring of BGL ‘CGMSGold’ by ‘MedtronikMINIMED’ (USA), polysomnography «SOMNOlab2 (PSG) Polysomnography (R & K)», the definition of HbA1c.
Results: See Table.
| Indicator | Group A n=25 Me [25;75] | Group B n=18 Me [25;75] |
| BGL during sleep time (mmol/l) | 4.50[4.00; 5.60] & | 8.20[7.50; 9.50] |
| BGL “after sleep” (mmol/l) | 7.90[7.40; 9.20]& | 9.65[8.50;11.30] |
| HBA1c (%) | 7.00[6.00;8.50]& | 8.95[7.50; 9.30] |
| Total sleep time (TST) (h) | 5.59 [4.80; 6.53]& | 4.90[4.23; 5.39] |
| REM (%) | 29.40[22.50;43.00]& | 39.90[24.70;41.40] |
| N1 (%) | 11.05[5.00; 18.30] | 7.00[4.70;14.00] |
| N2 (%) | 48.50[38.00;53.10] | 41.29[25.70;53.90] |
| N3 (%) | 4.00[2.70; 7.80]& | 2.65[0.00; 5.25] |
| N4 (%) | 3.50[1.90;13.50]& | 1.30[0.00; 7.50] |
| TST is longer in the group with BGL 4.50 mmol/L. REM sleep 10.5% increase in Group B. The shares represented a deep sleep are larger in Group A. In Group A the increase of TST decreases BGL during sleep (r=0.4098) and N2 sleep stage (r=0.4246). Decrease in N2 share decreases BGL during sleep (r=0.4997) and reduces N4 (r=0.5182), and has a negative coefficient with a value of REM sleep (r=−0.4330). In group B, REM sleep phase is inversely correlated with BGL “after sleep” (r=−0.5056), N3 (r=−0.8371), N4 (r=−0.7594). | ||
| &P<0.05 | ||
Conclusion: BGL 4.5 mmol/l during sleep increases the duration of sleep by increasing the N2, N4 and extending reduce REM sleep.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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