Endocrine Abstracts

Objective: To analyze correlation between the duration of diabetes mellitus (DM), renal function and androgenic state indicators in patients with DM type 1.

Material and methods: 191 males with DM 1 type in the age of 18–55 years. The control group included 25 almost healthy males in the age 21–41 years. The compensation of DM was estimated by the level of glycosylated hemoglobin. Also, the indicators of lipid profile, glomerular filtration rate MDRD, total testosterone, luteinizing hormone/follicle-stimulating hormone (LH/FSH), prolactin, sex hormone-binding globulin.

Results: It was defined that diabetes duration significantly it is above at patients with GFR <60 ml/min/1.73 m². In the group with GFR <60 ml/min/1.73 m² in the absence of compensation (Hb A1c >7.5%) more than LH, FSH, LH/FSH high levels and significantly lower levels of the general and free testosterone were noted significantly. At patients with GFR MDRD >60 ml/min/1.73 m² significant distinctions on the level of testosterone and gonadotrophins at various compensation of SD haven’t been revealed.

Conclusion: The revealed changes are important risk factors for development and progression of vascular complications and require appropriate arrangements.