Endocrine Abstracts

Purpose: Estimation of the continuous glucose monitoring system (CGMS) in the value of diabetes mellitus type 1 (DM1) control.

Materials and methods: 162 DM1 patients have been divided on 2 groups: 1st group with adequate control DM1 – glycated hemoglobin (HbA1C) ≤7.5% (n=38) and 2nd group with inadequate control – HbA1C>7.5% (n=124). All patients carried out CGMS with glycemia symmetrization scales and an estimation of probability of a dysglycemia, hypo- and hyperglycemias risks with calculation of indexes of risk (InR). High risk of a hypoglycaemia at InR more than 4.5; low – less than 2.5. The high risk of a hyperglycaemia at InR is more 9.0, low risk – less than 4.5. InR dysglycemias – a difference of InR hyper- and hypoglycemias.

Results: HbA1C level in the 1st group of patients was 6.75% (6.40; 7.25) – adequate control DM1, and in 2nd – 9.40% (8.30; 11.10) – inadequate control. InR in group 1 was less (8.25 (4.80; 14.70)), than in the 2nd group – 16.24 (10.45; 20.60) (P<0.001). In the group with inadequate control of DM1 InR of a hyperglycaemia has been raised at 85% of patients, in comparison to 48% of patients in the 1st group. Low InR of a hyperglycaemia in 2nd group was at 2% vs 1st group – 23% (P<0.001). InR hypoglycemias has made 5.60 (3.00; 10.50) in 1st group and 5.00 (1.60; 9.20) – in 2nd group. In the absence of differences between groups in InR hypoglycemias, InR of a dysglycemia significantly differed: 2.40 (3.00; 8.20) vs 9.85 (2.80; 18.55), (P<0.001). Hypoglycaemia InR exceeded 4.5 independently of adequacy of control DM1 (high risk of hypoglycemias) at 53% of patients of 1st group and at 62% of patients 2nd group. Low InR of a hypoglycaemia in 2nd group was at 19% that is significantly less (P<0.001), than in 1st group – 31%.

Conclusions: Inadequate control of HbA1C level among the patients with DM1 was observed three times more often than adequate. By results of CGMS the insulin therapy scheme has been optimizated according to a daily nutrition that allowed to reach improvements of control DM1.