Endocrine Abstracts

Purpose: To study the features the structural and functional state of the myocardium and blood vessels in patients with diabetes mellitus and arterial hypertension depending on omentin level.

Methods: A total of 65 patients (32 men and 33 women, mean age 51.6±5.2 years); 31- with type 2 diabetes and hypertension (group 1), 34 – with isolated arterial hypertension (group 2). Control group 20 healthy volunteers. We evaluated data transthoracic echocardiography and ultrasound thickness of the intima-media complex of the common carotid artery (IMC CCA). Omentin level in blood serum were determined by ELISA kit.

Results: Left ventricular hypertrophy (LVH) was diagnosed in 67.5% of patients in group 1 and 34.2% of patients in group 2 (P<0.05). IMC CCA patients of group 1 was significantly higher than in the comparison group (P<0.001). Omentin level in group 1 was reduced in comparison with the 2 – nd group and the control (262.24±10.46, ng/ml versus 296.43±12.72, ng/ml and 379.46±6.22 ng/ml, respectively, P<0.001). There was a negative correlation relationship between the content omentin plasma and left ventricular hypertrophy (r=−0.54; P<0.05) and IMC CCA (r=−0.46, P<0.05).

Conclusions: It was found that patients with type 2 diabetes and hypertension observed the progression of LVH and remodelling of the vascular wall, which are related to an imbalance omentin serum. Thus omentin reduction level can be considered as a biomarker of cardiovascular complications in these patients.