Endocrine Abstracts

Gonarthrosis is a severe problem of movement system. It is a restrictive health problem for modern human. And also; it is the other restrictive problem which coexistence of diabetes mellitus (DM) and gonarthrosis. Perhaps; an other parameter that is deserved to research for this coexistence is metabolic syndrome. Today, relationship between this clinical conditions are clear enough. And also two lobotuary parameters as Leptin and Nesfatin-1 are an other headstone for obesity and metabolic syndrome. Many studies established relationships between obesity and Leptin, Nesfatin-1 separately. Leptin is a hormone that is made by adipocytes and affects NeuroPeptid-Y levels. Its gene Ob is located in Chromosome-7. Leptin regulates food intake and gain weight. Nesfatin-1 is a hormone that is released by hypothalamus. It regulates hungry and fat sorage. We aimed to evaluate the levels of these two hormones in diabetic patients that have gonarthrosis. 101 patients were measured clinically and laboratory by X-rays, levels of insulin, Leptin and Nesfatin-1 on 2014-2016. 46 patients have Type 1 DM and 55 patients have Type 2 DM. All patients have gonarthrosis clinically and radiologically. 31 of all patients have overweight (25–29.9), 43 patients have obese (30–34.9), 20 patients have severely obese (35–39.9) and seven patients have morbidly obese (40 and up) accoding to BMI. In the Leptin results; there were high levels of 81 patients with insulin resistance. And these patients have increasing BMI. In the Nesfatin-1 results; there were significant lower in diabetic patients except in 11 patients. And also there were correlation between Nesfatin-1 lowerity and overweighty. It seem like Leptin levels is related with BMI directly. High insulin levels may increase Leptin levels. But; Nesfatin-1 is lower almost all patients with insulin resistance. Leptin and Nesfatin-1 has severe regulation on body energy storage. And they deserve more studies about diabetic population with gonarthrosis.