ECE2017 Eposter Presentations: Adrenal and Neuroendocrine Tumours Adrenal cortex (to include Cushing's) (86 abstracts)
The clinical course of patients with adrenal incidentaloma: Başkent University experience
Nazli Gulsoy Kirnap 1 , Ozlem Turhan Iyidir 1 , Yusuf Bozkus 1 , Lala Ramazanova 1 , Asli Nar 1 , Altug Kut 2 & Neslihan Tutuncu 1
1Department of Endocrinology, Baskent University Hospital, Ankara, Turkey; 2Department of Family Medicine, Baskent University Hospital, Ankara, Turkey.
The prevalance of incidentally discovered adrenal masses increased in last three decades. The major clinical concern is the risk of malignancy and hormone overproduction but most of them are non-fonctional and benign. Current practices in the management of adrenal incidentalomas reevaluated the follow-up suggestions considering low probability of the transformation of a benign and non-functional adrenal mass to a malignant or functional one. Therefore, in the present study we analysed the clinical course of patients with adrenal incidentaloma. We evaluated 203 consecutive patients (139 females, 64 males:mean age 55.8±0.8 years) who were referred to the Department of Endocrinology, Başkent University Hospital, between January 2007 and 2017. Among the 203 patients examined 171 had unilateral, 32 had bilateral adrenal masses. Mean size of tumors was 22.7±10.8 mm. In 157 (%77.3) patients’ adrenal mass was benign and non-functional, 21 (%10.3) had autonomous cortisol secretion, 9 (%4,4) had Cushing syndrome, 5(%2.5) had pheochromocytoma, 9 (%4,4) had primary hyperaldosteronism and, 2(%1) had adrenocortical carcinoma. Twentyone patients went adrenelectomy. Median follow up time was 3 (1–10) years. During the follow up the change in the size of adrenal mass was non significant (P=0.12) and there were no changes either in metanephrines and normetanephrines or in the activity of renin–aldosterone axis. There was a significant correlation between adenom size and cortisol levels after dexamethasone supression test in patients with autonomous cortisol secretion. As a result our study suggests that the risk of an adrenal adenoma initially diagnosed as benign or non-functional becoming malignant or hormonally active is low.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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