ECE2017 Eposter Presentations: Calcium and Bone Bone & Osteoporosis (37 abstracts)
Bone remodeling markers predict bone loss in premenopausal women
Gala Gutierrez Buey 1 , Sonsoles Botella 1 , Patricia Restituto 2 , Macarena Rodriguez Fraile 3 , Amparo Calleja 1 , María Llavero 1 , Javier Gargallo 1 , Carolina Perdomo 1 , Patricia Andrada 1 , Nerea Varo 2 & Juan C Galofré 1
1Department of Endocrinology, University of Navarra, Pamplona, Spain; 2Department of Clinical Chemistry, University of Navarra, Pamplona, Spain; 3Department of Nuclear Medicine. University of Navarra, Pamplona, Spain.
Aim: Bone turnover markers (BTMs) predict more rapid rates of bone loss. However, most of these studies have been carried out in postmenopausal women. Few prospective studies have examined the degradation marker C-terminal telopeptide of type I collagen (CTX) and the bone formation marker N-aminoterminal propeptide of type I collagen (P1NP) measured during the menopausal transition to predict the subsequent bone loss.
Methods: We performed a prospective cohort study including 72 healthy premenopausal women from de Endocrinology service at the Clinica Universidad de Navarra. Six women were lost in the follow-up and two were excluded because of treatment that affects bone. We measure demographic variables, CTX, P1NP and bone mineral density at baseline and five years later. SPSS 20.0 was used for statistical analysis. Differences between study groups were evaluated by Student’s t test for normally and Mann-Whitney-U test for non-normally distributed variables.
Results: Mean age at baseline was 49.2±0.3. After 5 years, there were no significant changes in baseline demographic characteristics (percentage of smokers, coffee intake, sun exposure and physical activity) although there was a significant increase in BMI (P=0.027).
Five years later, 69% became menopausal, 48.4% (31) had normal bone, and 51.6% (33) had pathological bone (below the expected range for age and/or osteoporosis). There was a significant decrease in BMD at 5 years of follow-up compared to baseline (femoral neck 0.92±0.1vs 0.87±0.1 (P=0.000), lumbar spine 1.17±0.19 vs 1.08±0.1 (P=0.000) and a significant increase in BTMs P1NP (ng/ml) 37.22±10 vs 52.23±21 (P=0.000) and CTX (ng/ml) 0.245±0.125 vs 0.441±0.233 (P=0.000). Increased levels of P1NP and s-CTX in the premenopausal group at baseline associated with pathological bone five years later (P<0.001 and P<0.001, respectively).
Conclusion: Our data suggest that measurement of CTX and P1NP in premenopausal women detects those patients who will suffer bone loss five years later.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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