ECE2017 Eposter Presentations: Calcium and Bone Bone & Osteoporosis (37 abstracts)
Primary hyperparathyroidism: hormonal profile and risk of complications
Alina-Andreea Gatu 1 , Cristian Velicescu 1, , Cristina Preda 1, , Voichita Mogos 1, , Carmen Vulpoi 1, , Simona Mogos 1, , Valentin Zaharia 2 , Adrian Aancute 2 & Dumitru Branisteanu 1,
1Gr. T Popa University of Medicine and Pharmacy, Iasi, Romania; 2St. Spiridon Emergency Hospital, Iasi, Romania.
Background: Vitamin D deficiency is frequently associated with primary hyperparathyroidism, but the impact of this association on disease evolution and complications is ill defined. Aims: to assess the role of vitamin D status on the metabolic profile and spectrum of complications at patients with primary hyperparathyroidism.
Materials and methods: Transversal study involving 42 patients with primary hyperparathyroidism submitted to parathyroidectomy. We evaluated serum calcium, phosphate, serum PTH and 25OHD3, bone mineral density by DXA (Hologic) and anamnestic episodes of bone fractures and kidney lithiasis. Fifteen patients had episodes of kidney lithiasis, whereas 27 patients did not develop this complication. Twenty patients were diagnosed with osteoporosis whereas 22 patients had bone mass in the range of normal or osteopenia. Data between groups were compared using the t test and were considered significant at P values < 0.05.
Results: Twenty-nine of the 42 patients had 25OHD3 in the range of deficiency (lower than 20 ng/ml) and 20 had severe 25OHD3 deficiency (lower than 10 ng/ml). Serum calcium and phosphate were similar irrespective of the presence or absence of complications. No differences were found between mean PTH and 25OHD3 levels of patients with or without osteoporosis. Patients with kidney lithiasis had, however, higher PTH (390+/− 90 pg/ml vs 209+/− 64 pg/ml, P<0.001) and lower 25OHD3 levels (12.8+/− 6 ng/ml vs 19.2+/− 7.8 ng/ml, P<0.05) than patients without kidney lithiasis.
Conclusions: D hypovitaminosis accompanies frequently primary hyperparathyroidism. Patients with higher risk of kidney lithiasis seem to have higher PTH and lower 25OHD3 levels.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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