Endocrine Abstracts

Aim of the study: Estimation of the frequancy of diabetes and prediabetes in patients with adrenal incidentaloma (AI) without hormonal activity.

Material and methods: The study comprised patients with AI without hormonal activity, verified by CT. The hormonal function of adrenal glands was determined according to the circadian rhythm of cortisol and/or dexametasone suppression test, ACTH, aldosterone, plasma renin activity, DHEAS, androstenedione, 17hydroxy progesterone, metanephrines in urine.

Physical examination included: the BMI, the waist circumference (norm <80 cm women, <94 cm men), blood pressure. The biochemical assays: fasting glycemia, OGTT (excluded patients with diabetes), fasting insulin and lipids level (total, HDL and LDL cholesterol, triglycerides).

Results: 125 patients were examined, aged 61.3±8.8 years, 72 (57.6%) women. Size of tumors were 27.6 mm ±15 mm. Carbohydrates disorders were observed in 62 (49.6%) persons aged 62.9±7.5 years, including 32 (25.6%) women. Abdominal obesity was diagnosed in 87 (69.6%), 56 (44.8%) women and 31 (24.8%) men. Diabetes was regonised in 16 (13%) patients, IFG in 24 (19.2%), IGT in 34 (27.6%). The concentration of fasting insulin was 8.9+/−5.5 μU/ml, higher in men then in women (9.16+/−5.65 vs 8.71+/−4.70; P>0.01). The concentration of total cholesterol was 218±49.7 mg/dl, HDL-cholesterol 59±21.1 mg/dl, LDL cholesterol 134±44.1 mg/dl, triglycerides 116±60 mg/dl; 83 (66.6%) of the patients had been diagnosed positive for dyslipidemia or were administered hypolipemic medications. Additionaly arterial hypertension was diagnosed in 99 (79.2%) patients, with the arterial systolic BP 131±15 mmHg, diastolic BP 80±9 mmHg.

Conclusions: 1) Diabetes was observed more often in patients with AI without hormonal activity then in the entire Polish population.

Patients with AI without hormonal activity are a risk group of prediabetes and diabetes.