Endocrine Abstracts

Aim: Hashimoto’s thyroiditis (HT) is the commonest autoimmune thyroid disease. Papillary thyroid cancer (PTC) is the most often thyroid cancer and its incidence is increasing yearly. It is not clear that HT is a predisposing factor for PTC. We studied PTC’s frequency among HT patients went to total thyroidectomy.

Materials and methods: Five hundred and thirty four patients done total thyroidectomy by general surgery were evaluated retrospectively from July 2015 to July 2016. Preoperative thyroid function tests, anti-thyroid antibodies, thyroid ultrasonography findings, fine needle aspiration biopsies of nodules and pathology results of total thyroidectomy were examined. According to pathology results, HT was detected in 139 patients. Patients with PTC and HT (group 1) and PTC without HT (group 2) were compared in terms of demographic characteristics, tumor size, focus number of tumor, invasion, extrathyroidal spread and lymphatic metastasis presence.

Findings: PTC was detected in 70 (%50.4) patients in group 1 and 156 (%39.5) patients in group 2 (P=0.026). There was no statistically significant difference between them in point of gender, age, tumor size, microcarcinoma-macrocarcinoma distribution, focus number of tumor, invasion, extrathyroidal spread and lymphatic metastasis. The number of patients with PTC who had at least 1 kind of high anti-thyroid antibody was greater in group 1 then group 2 (P<0.001).

Results: In our study,we determined more PTC among HT patients but we find no difference according to age, gender, tumor size, invasion and metastasis. By the way anti-thyroid antibody positiveness was higher in cancer patients of group 1. Long term follow-up studies are necessary for detecting the effect of HT to PTC prognosis.