ECE2017 Eposter Presentations: Thyroid Thyroid (non-cancer) (260 abstracts)
Cardiothyreosis: prevalence and risk factors
Meriem Yazidi 1, , Mélika Chihaoui 1, , Hiba Oueslati 1 , Ons Rejeb 1, , Sana Ouali 1, , Salsabil Rejaibi 1 , Fatma Chaker 1, & Hédia Slimane 1,
1Faculté de médecine de Tunis, Université de Tunis El Manar, Tunis, Tunisia; 2Hôpital La Rabta, Tunis, Tunisia.
Background: Cardiothyreosis (CT) or thyrotoxic heart is associated with higher morbidity and mortality than the other forms of hyperthyroidism. Its risk factors have been investigated in a limited number of studies. The aim of our study was to identify risk factors of CT in patients with hyperthyroidism.
Methods: We identified 538 patients with a hospital discharge diagnosis of hyperthyroidism from January 2000 to December 2015. Thirty five patients were diagnosed with CT. Their demographic, clinical and biological characteristics were retrospectively studied and compared with those of 72 controls randomly selected, using univariate and multivariate analysis.
Results: The prevalence of CT in patients hospitalized for hyperthyroidism was 6.5%. The cardiac complications were atrial fibrillation (AF) in 33 cases (6.1%) and cardiac heart failure (CHF) in 11 cases (2%). The risk factors of CT were age greater than 50 years (OR=13.1 (95% CI, 4.9–34.4)), low socioeconomic status (OR=2.8 (95% CI, 1.2–6.7)), low educational level (OR=3.1 (95% CI, 1.2–8.3)), history of hypertension (OR=3.5 (95% CI, 1.1–11.2)) and a multinodular toxic goiter as the etiology of hyperthyroidism (OR=4.6 (95% CI, 1.6–13.9)). After multivariate analysis, age greater than 50 years was the only independent risk factor of CT (adjusted OR=11.6 (95% CI, 2.7–49.5)). Severe biological hyperthyroidism (FT4> 3 times normal) was associated with a lower risk of CT (adjusted OR=0.2 (95% CI, 0.1–0.9)).
Conclusions: The prevalence of CT in patients with hyperthyroidism was 6.5%. The two types of cardiac disease observed were CHF and AF with a clear predominance of the latter. Advanced age was the only independent risk factor of CT.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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