Endocrine Abstracts

Background: PCOS patients associate an increased risk of glucose metabolism abnormalities. Although Hb A1c was suggested as a good diagnostic test for prediabetes/diabetes, in PCOS patients its diagnostic value could be inferior to OGTT as previously suggested. Aim of the study was to evaluate which are the clinical and paraclinical parameters associated with impaired glucose tolerance (IGT) in order to identify the profile of the patients that will benefit from OGTT.

Material and methods: 449 patients (mean age years, mean body mass index (BMI) kg/sqrm) diagnosed with PCOS based on Rotterdam criteria evaluated with OGTT were retrospectively selected from our PCOS database.

Results: From the 449 patients included in the study 23 (5.1%) had impaired fasting glycemic (IFG) and 28 (6.2%) IGT. Patients with prediabetes (IGT and IFG) were older, had higher BMI, waist circumference (WC), insulinemia (fasting and 2 h), HOMA-IR in comparison to patients with normal glucose. Patients with IFG were not different from those with IGT with respect to age, clinical and biochemical hyperandrogegism, adiposity, HOMA-IR, fasting insulinemia and metabolic parameters, except the 2 h insulinemia and serum FSH level which were higher and lower respectively in patients with IGT (P<0.05).

Conclusion: Our patients with IGT and IFG were similar in terms of clinical and paraclinical baseline parameters, making impossible their identification without an OGTT.