ECE2017 Eposter Presentations: Reproductive Endocrinology Female Reproduction (62 abstracts)
Efficacy comparison of oral rosuvastatin versus oral progesterone and bevacizumab on regression of surgically endometriotic implants in rats
Ayse Gul Kebapcilar , Tolga Tuyan Ilhan , Duygu Dursunoglu , Kubra Kurt , Suleyman Hilmi Ipekci , Suleyman Baldane , Mustafa Gazi Ucar , Cem Onur Kirac , Levent Kebapcilar & Cetin Celik
Selcuk University, konya, Turkey.
Aim: Thirty female Wistar albino rats with surgically endometriotic implants were randomly randomized into three treatment groups: oral rosuvastatin (20 mg kg per day; oral rosuvastatin group 1; n=10), oral progesterone (Dienogest group 2; n=10), and intraperitoneal bevacizumab (2.5 mg/kg of single intaperitoneal injection of bevacizumab; group 3; n=10) respectively, for 10 day and post-treatment variables were compared.
Results: The endometrium foci as were measured on days 1 and 10. Rosuvastatin group showed higher reduction for the glandular epithelium and uterine vessels of histopathological scores values than progesterone group (both, P<0.017; respectively). The median glandular epithelium and uterine vessels and histopathological scores values did not show statistically significant difference among group 1 and group 3 (P>0.017). No significant different reduction was observed in between the three groups for the myometrium, endometrial stroma, in histopathological scores (P>0.017). Endometrial thickness and uterine volume values analyzed in all treatment groups. Endometrial thickness values and uterine volume values was more significantly reduced in the oral rosuvastatin medication than oral progesterone group (both, P<0.017; respectively). Moreover, endometrial thickness and uterine volume values were not different in groups I compared with group 3 (P>0.017).
Conclusion: In conclusion, rosuvastatin and intaperitoneal injection of bevacizumab may causes more significant regression of surgically endometriotic implants in rats than oral progesterone medications.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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