ECE2017 Eposter Presentations: Reproductive Endocrinology Developmental endocrinology (1 abstracts)
Age and developmental stage dependent relationship between plasma concentrations of leptin, luteinizing hormone, follicle stimulating hormone, prolactin, testosterone and inhibin B in boys between the age of 1 and 20 years
Afzaal Ahmed Naseem 1 , Mazhar Qayyum 1 , Maleeha Akram 1 , Zubaria Iqbal 1 , Fahim Tahir 2 , Kiran Afshan 3 , Sarwat Jahan 3 & Syed Shakeel Raza Rizvi 1
1Department of Zoology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi/Punjab, Pakistan; 2Reproductive Physiology, Public Health Laboratories Division, National Institute of Health (NIH), Islamabad, Pakistan; 3Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Leptin is regarded as an essential adipokine for controlling energy homeostasis, caloric intake reduction and increase of caloric expenditure by negative feedback mechanisms via receptors in the hypothalamus. Puberty is said to be triggered by leptin, which signals the hypothalamus that adequate fat reserves are available for initiation of energetically costly process of reproduction. Leptin activates gonadotropin releasing hormone (GnRH) system, which stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretion from pituitary gonadotropes and subsequent secretion of testosterone (T) from testes. Nevertheless, it is not clear whether leptin has any association with the secretion of FSH, prolactin (PRL) and inhibin B during puberty. This study examined possible associations between plasma concentrations of leptin and LH, FSH, PRL, T, and inhibin B at different ages and developmental stages in boys between 1 and 20 years (27 boys/age group). The concentrations of leptin, LH, FSH, PRL, T and inhibin B were determined using specific ELISA. Data were analyzed using Student’s t-test, ANOVA and Pearson correlation r. The concentrations of leptin and LH were positively correlated at 1st, 4th−10th, 12th, 16th, 20th year and at infancy and early puberty. Leptin and FSH concentrations were positively correlated at 1st-3rd, 8th−10th, 12th, 13th, 15th, 16th, 18th, 20th year and at infancy, pre-puberty and early puberty. Leptin and PRL levels were positively correlated at 1st, 3rd, 5th, 6th, 9th, 10th, 12th-14th, 19th year and at infancy, pre-puberty and early puberty. Leptin and T concentrations were positively correlated at 1st, 3rd, 6th, 7th, 9th, 10th, 12th and 16th year and at infancy and early puberty. Leptin and inhibin B levels were positively correlated at 1st, 3rd−8th, 10th, 12th, 15th-19th year and at infancy, early and late puberty. Thus, leptin and LH, FSH, PRL, T and inhibin B are positively correlated only at early puberty.
Volume 49
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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