ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Obesity (81 abstracts)
Metabolic profile reversal after bariatric surgery
Daniela Gallo 1 , Silvia Ippolito 1 , Giovanni Veronesi 1 , Eugenia Dozio 1 , Francesco Frattini 2 , Eugenia Trotti 1 , Adriana Lai 1 , Lorenza Sassi 1 , Jessica Sabatino 1 , Elvira Masiello 1 , Paola Premoli 1 , Eleonora Bianconi 1 , Sara Rosetti 1 , Claudio Cusini 1 , Maria Laura Tanda 1 , Gianlorenzo Dionigi 2 , Luigi Bartalena 1 & Eliana Piantanida 1
1Department of Medicine and Surgery, University of Insubria, Varese, Italy; 2Research Center for Endocrine Surgery, University of Insubria, Varese, Italy.
Bariatric surgery is the most-effective treatment for morbid obesity, superior to medical treatment. Metabolic syndrome (MS) is a condition characterized by multiple major risk factors for coronary heart disease, diabetes, fatty liver, and several cancers; the main, diagnostic, components of MS are low HDL-cholesterol (<40 mg/dl in man, <50 mg/dl in woman), raised triglycerides (>150 mg/dl), blood pressure >130/85 mmHg, fasting plasma glucose >100 mg/dl and waist circumference >94 cm in man and >80 cm in woman. Indeed, in addition to weight loss, changes in metabolic profile after bariatric surgery could improve long-term outcomes. Complete demographic, clinical and laboratory data from 38 people (35 women, mean age 41±13 years) undergoing bariatric surgery and followed by a dedicated clinical team were analyzed. Descriptive statistics detailed clinical characteristics of the cohort of patients. Paired T-test compared baseline clinical parameters, lipid and glycemic profile index at three (T3) and six (T6) months after surgery. General Linear Model for Repeated Measure compared the five conditions defining MS over time. Weight, BMI, waist circumference and systolic blood pressure decreased significantly at T3 and T6, compared to baseline [all P<0.05]. Triglycerides and LDL cholesterol decreased at T3 and T6, HDL notably raised at T6 [all P<0.05]. Fasting plasma glucose and HbA1c decreased at T3 and T6; HOMA index improved over time [all P<0.05]. Prevalence of MS according to IDF/AHA/NHLB harmonized definition in our population was 50% at baseline, 10 times higher for age than average prevalence in literature; at 6 months such prevalence decreased to 16%. In conclusion, in our population of patients undergoing bariatric surgery and a dedicated follow-up program, we observed a trend towards a noticeable improvement of the metabolic profile in the mid-term.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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