Endocrine Abstracts

Background and objective: Hyperglycemia exacerbates multiple deleterious derangements and this process would influence the clinical outcome in diabetic patient. The objective of this study is to know the effect of admission hyperglycemia on clinical outcome of ischamic stroke patients admitted in Sardjito General Hospital.

Method: Observational cohort study over 5 months’ period from August 1-2016 to December 31-2016 was done. All patients 18 years old and above, admitted as stroke ischaemic patients in Sardjito General Hospital Yogyakarta were screened. In order to qualify, patient were subjected to initial random blood sugar determination upon admission and monitored to 48–72 h. Capillary blood glucose was monitored using blood glucose monitor device by Bayer. Hyperglicemia status is blood glucose above 200 mg/dl. Clinical outcome was evaluated and recorded using The National Institutes of Health Stroke Scale (NIHSS) on day 1 and discharge. Participants who are below 18 years old, previously stroke, or those with acute co-morbid disease like acute myocardial infarction, pneumonia, or critical infection, ketoacidosis diabeticum, hyperglicemia hyperosmolar state were all excluded. All patients managed according to guidelines for stroke and hyperglycemia.

Result: Sixty four eligible subjects admitted at Sardjito General Hospital, 12 (19.35%) were hyperglycemia and 50 (80.65%) normoglycemia. The mean value of blood glucose at admission are 153.45+69.09 mg/dl. Patients who have worsening clinical outcome at dischare are 18 (29.03%) based on NIHSS. Six patients (44.44%) who had hyperglicaemia had worsening clinical outcome and four patients (9.09%) did not have worsening clinical outcome (P-value 0.003; OR 8; min 2 001–max 31 988).

Conclutions: Hyperglicaemia at admission have correlate with worsening of clinical outcome ischaemic stroke patients.

Keywords: Hyperglycemia; Ischaemic stroke patients; The National Institutes of Health Stroke Scale.