ECE2017 Eposter Presentations: Adrenal and Neuroendocrine Tumours Pituitary - Clinical (1 abstracts)
The risk of hypotension, evaluated by ambulatory blood pressure monitoring, during fasting and outside fasting in patients with adrenal insufficiency
Melika Chihaoui 1 , Wafa Grira 1 , Meriem Yazidi 1 , Ons Rejeb 1 , Fatma Chaker 1 , Ibtissem Oueslati 1 , Jihane Bettaieb 2 & Hedia Slimane 1
1Department of Endocrinology, Faculty of Medicine of Tunis, La Rabta Hospital, University of Tunis El Manar, Tunis, Tunisia; 2Department of Medical Epidemiology, Faculty of Medicine of Tunis, Pasteur Institute of Tunis, University of Tunis El Manar, Tunis, Tunisia.
The risk of hypotension during Ramadan fasting in patients with adrenal insufficiency is unknown. The aim of our study was to evaluate objectively this risk.
Methods: It is a prospective case-crossover study on 28 patients with known and treated AI. Patients had no hypertension and were regular fasters. All patients underwent a clinical examination and a 24-hours blood pressure monitoring during Ramadan fasting then outside fasting.
Results: There were 23 women. The mean age was 37±14 years. It was a central adrenal insufficiency in 26 patients. The mean duration of the disease was 9±8 years. The mean daily dose of hydrocortisone was 19±3 mg. Systolic hypotension (<90 mmHg) did not occur during fasting and occurred in two cases outside fasting. Diastolic hypotension (<60 mmHg) occurred in 12 cases during fasting and in 13 cases outside fasting without a significant difference. All cases of hypotension were asymptomatic. The levels of systolic and diastolic blood pressure during the 24 h and during the fasting period (from pre dawn to sunset) did not significantly differ between the fasting day and the non-fasting day.
Conclusion: Blood pressure levels during fasting were comparable to those outside fasting and there was not an increased risk of hypotension during fasting.
Volume 49
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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