Endocrine Abstracts

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L-T4 monotherapy remains the standard treatment of hypothyroidism, as RCTs comparing T4 and T4+T3 did not indicate superiority of the combination therapy. However, the issue is far from settled, as these RCTs can be criticized and 5–10% of patients on T4 have persistent complaints.i) Has T4+T3 therapy a true effect on serum thyroid hormones? Under T4 monotherapy serum FT4 is higher and serum FT3 is lower than in healthy subjects, giving ris...

Advances in stem cell biology and thyroid development have opened up the possibility of developing tissue replacement therapy for hypothyroidism. Indeed, in this session the development from stem cells of functioning thyroid tissue in mice will be reviewed. In addition new insight into the development of this technology in human cells will also be discussed. Importantly, advances in this field may lead to new therapeutic options in congenital or post-surgical hypothyroidism.</...