Endocrine Abstracts

One of the most surprising and inspiring experimental models for type 2 diabetes therapy is gastric bypass surgery. Recent 5-year results have demonstrated massive improvements in glycaemic control and body weight, lipids and quality of life after surgery compared to intensive medical therapy (the Stampede trial). Therefore, it is imperative to identify the responsible factors with a view to utilize this knowledge for future therapy without surgery. Substantial evidence sugges...

The incretin hormone Glucagon-like peptide-1 (GLP-1) has various non-glycaemic properties. Among those, cardiovascular effects have been described in animal studies and in clinical studies in patients with type 2 diabetes that have been treated with GLP-1 receptor agonists (GLP-1RA). In animal studies, GLP-1 and GLP-1RA have lead to a decrease in ischaemic areas in artificial myocardial infarct models. Additionally, in some clinical studies, an improvement in left ventricular ...

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