Endocrine Abstracts

Islet autoantibodies are strong predictors of type 1 diabetes (T1D), as positivity for multiple, i.e.is two or more, autoantibodies is associated with a risk of around 70% of progression to clinical disease over the next 10 years. Autoantibodies do not, however, predict when T1D will present clinically. We have assessed the utility of signs of dysglycemia for the prediction of the time of disease manifestation and observed that an increase in HbA1c of 10% over 3–12 months...

Worldwide diabetes epidemic leads to exponential increase in incidence and prevalence of associated co-morbidities and mortality. During the last 10 years we have devoted to investigate how clinical and genetic biomarkers can be used to facilitate prediction of these life-threatening hazards. Accumulating evidence from our large prospective studies indicate that decline in insulin secretion adjusted for the degree of insulin sensitivity is the key factor contributing to overt ...

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