Endocrine Abstracts

Fibroblast growth factor 21 (FGF21) is an endocrine and paracrine factor that is produced in many tissues in response to metabolic stress, including several nutrient and dietary conditions. In addition to its physiologic role in regulating the adaptive response to these conditions, pharmacologic administration of FGF21 to obese animals causes weight loss and improves insulin sensitivity. The diverse actions of FGF21 are mediated through a unique receptor complex that is compos...