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Endocrine Abstracts

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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Oral Communications

Reproduction & Endocrine Disruption

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Pituitary Clinical
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Thyroid Cancer

ea0049oc13.1 | Reproduction & Endocrine Disruption | ECE2017

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ea0049oc13.2 | Reproduction & Endocrine Disruption | ECE2017

Thyroid peroxidase antibodies do not predict outcome in 900 women with recurrent pregnancy loss

Bliddal Sofie , Svarre Nielsen Henriette , Krogh-Rasmussen Aase , Marie Kolte Astrid , Bjarne Christiansen Ole , Henrik Nielsen Claus , Feldt-Rasmussen Ulla

Introduction: Thyroid autoimmunity has been associated with pregnancy loss. A possible mechanism is an overactive maternal immune system leading to rejection of the fetal allograft. In women with recurrent pregnancy losses (RPL), we investigated the association of thyroid peroxidase antibodies (TPOAbs) with number of losses and outcome of first pregnancy after referral.Methods: Prospective study of women with RPL (≥3) followed at the RPL Unit, Cope...
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ea0049oc13.3 | Reproduction & Endocrine Disruption | ECE2017

Sertoli cell expressed hydroxysteroid (17beta) dehydrogenase 1 is required for male fertility

Hakkarainen Janne , Jokela Heli , Zhang Fuping , Kotaja Noora , Sipila Petra , Poutanen Matti

: Hydroxysteroid (17beta) dehydrogenase 1 (Hsd17b1) is a steroidogenic enzyme catalyzing the conversion of estrone (E1) to estradiol (E2), and androstenedione (A-dione) to testosterone (T). We have shown that the deletion of Hsd17b1 gene in mice resulted in the failure of ovarian estrogen production and subfertility. In this study, we clarified the role of Hsd17b1 in male reproduction. The data revealed that in mice Hsd17b1 mRNA is highly expressed in the Sertoli cells at the ...
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ea0049oc13.4 | Reproduction & Endocrine Disruption | ECE2017

Diabetes mellitus: a new cause of male infertility

Angela Condorelli Rosita , La Vignera Sandro , Cannarella Rossella , Maria Mongioi Laura , Eugenio Calogero Aldo

Introduction: Diabetes mellitus (DM) may cause male infertility acting with pre-testicular, testicular and post-testicular mechanism.Aim: To evaluate the presence of male infertility and the mechanisms of sperm damage in diabetic patients in childbearing age.Patients and methods: Thirty-four patients with DM1, 55 with DM2 and 100 healthy fertile men (controls) were enrolled. Diabetic patients were further divided into three groups ...
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ea0049oc13.5 | Reproduction & Endocrine Disruption | ECE2017

Urinary cadmium excretion is associated with increased synthesis of cortico- and sex steroids in a family-based Swiss population study

Bochud Murielle , Jenny-Burri Judith , Pruijm Menno , Ponte Belen , Guessous Idris , Ehret Georg , Petrovic Dusan , Dudler Vincent , Haldimann Max , Escher Genevieve , Dick Bernhard , Mohaupt Markus , Paccaud Fred , Burnier Michel , Pechere-Bertschi Antoinette , Martin Pierre-Yves , Vogt Bruno , Ackermann Daniel

Background: Cadmium (Cd) is considered as a human carcinogen. A potential intermediate mechanism could be hormone-related by disturbing steroidogenesis in gonads and adrenal glands. We tested whether urinary Cd excretion, as a marker of long-term exposure, is associated with the urinary steroid profile in the general adult population.Methods and Findings: The Swiss Kidney Project on Genes in Hypertension (SKIPOGH) is a multicentric family-based populatio...
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Endocrine Abstracts
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