Endocrine Abstracts

Purpose: Somatotrophinomas have been shown to demonstrate T2-weighted signal intensity (WSI) on MRI that is correlated with clinicopathological findings and response to treatment. Therefore, we aimed to investigate these correlations in functional pituitary adenomas, including prolactinoma and corticotrophinoma. Material and MethodsPatients with somatotrophinoma (n=87), prolactinoma (n=78) and corticotrophinoma (n=33) were invo...

Objective: To collect clinical and treatment outcome data in a large patient cohort, and specifically to report experience with temozolomide (TMZ).Design: Cohort study based on an electronic survey open for participation to ESE members Dec 2015-Nov 2016.Results: Reports on 167 patients, 40 pituitary carcinomas, and 127 aggressive pituitary tumours were obtained. Median age at diagnosis was 43 (range 4–79) years. 59% of tumours...

Introduction: Although in-vitro models suggest GH-induced differentiation, migration and survival of astrocytes and oligodendrocytes, no studies had been published in-vivo. We want to evaluate the efficacy and safety of GH associated with physical therapy compared to placebo in patients with complete spine injury (SI) and associated GH deficiency (GHD).Methods: Eighteen Patients with complete SI were screened for GHD (glucagon test). 12 severe (...

Background: Hypercortisolism in Cushing’s disease (CD) is associated with high cardiovascular risk. Hemodynamic disturbances, especially excessive vasoconstriction and elevated blood pressure (BP), may contribute to accelerated myocardial remodeling. Early identification of subclinical left ventricular (LV) dysfunction may be crucial for optimizing treatment and reducing mortality in patients with CD.Purpose: The aim of this study was to assess the ...

Acromegalic osteopathy is an emerging complication of chronic GH excess characterized by increase in bone turnover, deterioration in bone microarchitecture and high risk of vertebral fractures (VFs). Medical therapies may exert direct effects on peripheral targets leading to improvement of clinical outcomes regardless of biochemical control of acromegaly. In this longitudinal study, we compared the effects pegvisomant (PegV) and somatostatin receptor ligands (SRLs) on VF risk ...